Experience with:

• Osteoporosis: ovariectomy and orchiectomy in large and small species, proof-of-concept, short and long-term, young and aged populations
• Osteonecrosis: tooth extraction, rodent
• Bone healing: large and small species, short and long-term, young and aged populations
• Arthritis: osteoarthritis, rheumatoid arthritis
• Bone and muscle disuse, rodent
• Thyroparathyroidectomy (TPTx) rat: screening or short term model to assess calcium modulators
• Uremic rat (5/6 nephrectomy): screening or short-term model to assess PTH or vitamin D modulators, long-term model of chronic kidney disease (CKD) to assess mineral and bone disease (CKD-MBD)
• Schenk rat model: screening model used primarily for anti-resorptive agents

Selected publications:

Animal Models in Bone Research, Chapter 4 in Bone Toxicology. 2017 Kimmel DB. Eds: SY Smith, A Varela, R Samadfam, Springer: Molecular and Integrative Toxicology series

Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption. Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G. Osteoporos Int. 2018 Mar;29(3):685-69.

One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats. Varela A, Chouinard L, Lesage E, Guldberg R, Smith SY, Kostenuik PJ, Hattersley G. Bone. 2017 Feb;95:143-150.

One year of abaloparatide, a selective activator of the PTH1 receptor, increased bone formation and bone mass in osteopenic ovariectomized rats without increasing bone resorption.  Varela A, Chouinard L, Lesage E, Smith SY, Hattersley G.  J Bone Miner Res. 2017 Jan 32(1):24-33.

Does activin receptor blockade by bimagrumab (BYM338) pose detrimental effects on bone healing in a rat fibula osteotomy model?  Tankó LB, Goldhahn J, Varela A, Lesage E, Smith SY, Pilling A, Chivers S.  Calcif Tissue Int. 2016 May 11. [Epub ahead of print]

Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized rats.  Smith SY, Samadfam R, Chouinard L, Awori M, Bénardeau A, Bauss F, Guldberg RE, Sebokova E, Wright MB. J Bone Miner Metab. 2015 Nov;33(6):625-41.

Effects of denosumab, alendronate, or denosumab following alendronate on bone turnover, calcium homeostasis, bone mass and bone strength in ovariectomized cynomolgus monkeys.  Kostenuik PJ, Smith SY, Samadfam R, Jolette J, Zhou L, Ominsky MS. J Bone Miner Res. 2015 Apr;30(4):657-69.

The effects of bazedoxifene in the ovariectomized aged cynomolgus monkey.  Smith SY, Jolette J, Chouinard L, Komm BS. J Bone Miner Metab. 2015 Mar;33(2):161-72.

Long-term treatment with eldecalcitol (1α, 25-dihydroxy-2β- (3-hydroxypropyloxy) vitamin D3) suppresses bone turnover and leads to prevention of bone loss and bone fragility in ovariectomized rats.  Takeda S, Smith SY, Tamura T, Saito H, Takahashi F, Samadfam R, Haile S, Doyle N, Endo K. Calcif Tissue Int. 2015 Jan;96(1):45-55.

Evaluation of cartilage and bone degradation in a murine collagen antibody-induced arthritis model.  Oestergaard S, Rasmussen KE, Doyle N, Varela A, Chouinard L, Smith SY, Qvist P, Karsdal MA.  Scand J Immunol. 2008 Mar;67(3):304-12.

Effects of treatment of ovariectomized adult rhesus monkeys with parathyroid hormone 1-84 for 16 months on trabecular and cortical bone structure and biomechanical properties of the proximal femur.  Fox J, Miller MA, Recker RR, Turner CH, Smith SY.  Calcif Tissue Int. 2007 Jul;81(1):53-63.

Effects of daily treatment with parathyroid hormone 1-84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeys.  Fox J, Miller MA, Newman MK, Recker RR, Turner CH, Smith SY.  Bone. 2007 Sep;41(3):321-30.

Treatment of skeletally mature ovariectomized rhesus monkeys with PTH(1-84) for 16 months increases bone formation and density and improves trabecular architecture and biomechanical properties at the lumbar spine.  Fox J, Miller MA, Newman MK, Turner CH, Recker RR, Smith SY.  J Bone Miner Res. 2007 Feb:22(2) 260-73.

Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength.  Fox J, Miller MA, Newman MK, Metcalfe AF, Turner CH, Recker RR, Smith SY.  Calcif Tissue Int. 2006 Oct;79(4):262-72.

Early elevation in circulating levels of C-telopeptides of type II Collagen Predicts structural damage in articular cartilage in the rodent model of Collagen-induced Arthritis. Oestergaard S, Chouinard L, Doyle N, Smith SY, Tanko LB, Qvist P.   Arthritis Rheum. 2006 54(9): 2886-90.

The utility of measuring C-terminal telopeptides of collagen type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint diseases.  Oestergaard S, Chouinard L, Doyle N, Karsdal MA, Smith SY, Qvist P, Tankó LB. Osteoarthritis Cartilage. 2006 Jul;14(7):670-9.

Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys.  Smith SY, Recker RR, Hannan M, Muller R, Bauss F. Bone. 2003 32:45-55.

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